Located in Via del Babuino close by the Spanish Steps and directly across the street from the much pricier De Russie, the Hotel Piranesi is situated inside the ancient Palazzo Nainer. The building was redesigned at the beginning of the 19th century by the famous architect Valadier and has since been completely remodeled to maintain its original structure while offering all modern comforts.

The hotel rooms, lounges and common areas are furnished with elegant pieces of furniture that have been refurbished with a splendid selection of fabrics from a private collection belonging to the building's owners. The hotel's 19 rooms and 11 suites feature parquet floors and marble bathrooms - some with small balconies. The suites boast terraces overlooking the impressive Piazza del Popolo. The hotel features a meeting room, a well-equipped fitness room, and a sauna.